UNFPA humanitarian action in countries is supported by offices at regional and headquarter levels. This includes support in quality programming, human resources, safety and security, supplies and logistics, finance and administration, communications and advocacy, and resource mobilization.

In 2022, the Humanitarian Response Division and the regional offices coordinated and facilitated the scaling up of humanitarian action, particularly in high-profile emergencies such as Ukraine, Afghanistan, northern Ethiopia, Somalia, Yemen, Syria, the Horn of Africa and Central Sahel.